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一位是作风矫健、机智幽默的联邦特工威斯特，一位是爱耍聪明的易容大师高登，这两个看似一山不容二虎的狠角色却被总统同时召见了，原因是授命他们一同追捕一名神秘毒辣的科学家连环杀手。威斯特和高登只好在摩擦碰撞中培养默契，竟然很快成为一对绝配拍档。经过调查，两人发现原来幕后黑手竟然是曾经的天才博士勒弗里斯，他因在一次实验中失去双腿，只好永久呆在轮椅上，然而残缺的个性与对社会的怨恨让他开始到处作乱，甚至发明了一架巨型的蜘蛛机器滥杀无辜，并企图谋杀总统，统治美国。危机迫在眉睫，威斯特和高登分头来到新奥尔良，驾驶着一列布满机关的火车迎战蜘蛛博士，一场古怪武器间的斗智斗勇已悄然展开……。Detective Murdoch finds that the man behind a flying machine that crashes in Toronto is none other than his old nemesis, James Pendrick. He learns that Pendrick is hoping to win a $1 million prize for the first controlled flight. A body is found in the rubble of the crash but someone is clearly out to steal his invention. Murdoch also has to deal with Ottawa-based spymaster Ter...。